After completing his M.B., B.Ch. at the University of the Witwatersrand in 1980, Prof Donde graduated with his M. Med. Rad(T) Radiation Oncology from the same institution, in 1989.
During this time (1984 to 1989) he was Registrar, Department of Radiation Oncology, Johannesburg Hospital and University of the Witwatersrand and, for 11 years following this, he consulted to and lectured in the Department of Radiation Oncology at this hospital and university, where he became Senior Specialist and Senior Lecturer.
In 2001 Prof Donde was appointed Associate Professor and, in 2002, was promoted again – to the position of academic head of the Department of Radiation Sciences, University of Witwatersrand, where he was also a member of the Senate and the Executive Committee of the School of Medicine, Faculty of Health, as well as Chairman of Local Control for Radiation and of the Quality Control Committee at Johannesburg Hospital.
From 2004, Prof Donde was Chief Specialist of the Division of Radiation Oncology, Convener of the College of Medicine for examination in radiation oncology, and Secretary at the College of Radiation Oncologists, College of Medicine South Africa.
In 2009 Professor Donde joint the DMO team at Sandton Oncology Centre. He has an honorary appointment with the University of the Witwatersrand and continues to attend academic meetings at the University and University teaching hospitals regularly.